According to this
Nanoxia DS1 cools better and is quieter than Define R4.
Sorry, but those Anandtech figures are hardly credible: according to Anandtech
the Nanoxia have the same noise level at every fan speeds, which does not seems physically possible, and it should have a cooling prowess among the best available, but without having any huge vent (so common on any high performance competitor), which also doesn't seem physically possible (I think it don't act as a refrigerator). Summarizing, it looks too good to be true.
Set aside what would seem as flying donkeys, the DS1 is a good performer and it's quiet.