Yes: Up to 2x120mm fans for intake from the bottom, exhaust in the rear and through the opposite side panel.
In-Win illustration.
The PSU is at the top, and also contributes to the exhaust. (At the cost of being cooled with pre-heated air, unlike most other modern cases. But with 90+% PSU efficiency common these days, I don't expect much negative effect from that.)
Why would intake at the bottom be less efficient than the front? Shouldn't it be about the same, perhaps with the bottom intake a bit better for the graphics card and slightly worse for the CPU?
Tilltech: I don't know, but I'm considering the same case. With two 120mm fans at the bottom and a 120mm exhaust fan in the back, plus the exhaust contribution from a semi-passive power supply, I imagine the cooling should be fine. Perhaps not enough for an overclocked Skylake-X or something, but for a standard desktop at stock speeds it looks fine to my eyes.
It will probably not be as quiet as say the Fractal Nano S, which has sound dampening material on the inside, and cases with a window lets more noise through. But if the components (and fans) are sufficiently low noise in the first place - aftermarket heat sink for the CPU, semi-passive graphics and power supply - it should still be fine.
That's what I'm thinking so far, but I'm open for corrections.